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Cardiovascular risk stratification was recently presented as an accessible outcome for AI algorithms and retinal vascular imaging. Initially, researchers focused on high-incidence ocular diseases such as diabetic retinopathy, age-related macular degeneration or glaucoma. In the field of retinal vascular imaging, AI techniques have found a particularly good fit. However, recent rapid developments in artificial intelligence (AI) in medical imaging hold promise for improved screening, diagnostics and community healthcare. The field of ocular biomarkers of systemic disease is now conceptualized as “oculomics” research. Hence, impaired retinal vascular network patterns were associated with increased cardiovascular risk score assessment, cardiovascular mortality and cardiovascular risk factors. Numerous studies have investigated the relationship between retinal microvascular abnormalities and systemic system. The retinal vasculature, which can be accessed noninvasively, represents a unique biological model for the study of microvascular abnormalities and pathology associated with cardiovascular disease. However, the microcirculation has been difficult to access, and thus robust microvascular biomarkers have yet to be developed. Indeed, it is recognized that small-vessel or microvascular pathology plays a major role in processes leading to the development of cardiovascular disease (CVD) and its risk factors. Fundus and OCT-A features were associated not only with vascular ocular disorders, but also with systemic vascular diseases. These fundus photograph and OCT-A retinal vascular metrics were shown to be correlated with the detection, severity and progression of various clinical eye diseases (e.g., diabetic retinopathy, vascular occlusion, glaucoma). Effective quantitative retinal vascular metrics, such as vessel density, vessel perfusion and flow index, are available with OCT-A devices. With OCT-A, it is possible to describe the retinal vascular network at capillary level in different plexuses. For example, data on vessel calibre, tortuosity, branching angle and retinal fractal dimension can be extracted from fundus photographs using semi-automated analysis software with reproducible algorithms. Technological developments in modalities such as retinal fundus photography, optical coherence tomography–angiography (OCT-A) or adaptive optics have made it possible to derive accurate retinal vascular metrics. Over the past 2 decades, interest in retinal vascular imaging has been increasing. This literature review is intended to summarize the state of the art in oculomics and cardiovascular disease research. A PubMed search was conducted until August 2022 and yielded relevant peer-reviewed articles based on a set of inclusion criteria. Despite the large volume of associated research, the role of retinal biomarkers in the screening, monitoring, or prediction of systemic vascular disease remains uncertain. A new approach called “oculomics” using retinal image datasets and artificial intelligence algorithms recently increased the interest in retinal microvascular biomarkers. Thus, the structure of retinal vessels could be considered a witness of the systemic vascular status. For more than 10 years, different research teams have been working on developing software to enable automatic analysis of the retinal vascular network from different imaging techniques (retinal fundus photographs, OCT angiography, adaptive optics, etc.) and to provide a description of the geometric characteristics of its arterial and venous components. In ophthalmology, retinal vascular network imaging is simple and noninvasive and can provide in vivo information of the microstructure and vascular health. Understanding the underlying mechanisms and improving identification of people with a higher risk profile of systemic vascular disease through noninvasive examinations is crucial. The healthcare burden of cardiovascular diseases remains a major issue worldwide. Leukemias and lymphomas: Studies looking at a possible link between personal hair dye use and the risk of blood-related cancers such as leukemia and lymphoma have had mixed results. However, studies looking at people who have their hair dyed have not found a consistent increase in bladder cancer risk. These studies have looked at 2 groups of people:īladder cancer: Most studies of people exposed to hair dyes at work, such as hairdressers and barbers, have found a small but fairly consistent increased risk of bladder cancer. Most of the studies looking at whether hair dye products increase the risk of cancer have focused on certain cancers such as bladder cancer, non-Hodgkin lymphoma, leukemia, and breast cancer. It’s not clear how these results might relate to people’s use of hair dyes. Although studies have shown that some of the dye applied to an animal’s skin is absorbed into the bloodstream, most have not found a link between skin application and cancer risk. Some of the ingredients used in hair dyes (including certain aromatic amines) have been shown to cause cancer in lab animals, usually when the animals were given large amounts of the dyes over a long period of time. In fact, many studies classify personal hair dye use based on whether it took place before or after 1980. Studying exposure to hair dyes from decades ago may not be the same as studying current exposures. Early hair dyes contained chemicals, including some aromatic amines, which were found in the late 1970s to cause cancer in lab animals, so hair dye manufacturers changed some of them in their products. On top of this, the ingredients in hair dyes have changed over time. Studying hair dyes can be hard because not all hair dyes are the same – they can contain any of thousands of different chemicals. In most cases neither type of study provides enough evidence on its own, so researchers usually look at both human and lab-based studies when trying to figure out if something might cause cancer. Studies in people (epidemiologic studies).Lab studies (studies done using lab animals or cells in lab dishes).A substance that causes cancer or helps cancer grow is called a carcinogen. Researchers use 2 main types of studies to try to figure out if a substance can cause cancer. Studies have looked most closely at the risks of blood cancers (leukemias and lymphomas), bladder cancer, and breast cancer. Researchers have been studying a possible link between hair dye use and cancer for many years. Many of the concerns about hair dyes possibly causing cancer have focused on people who work with them. People who work around hair dyes regularly as part of their jobs, such as hairdressers, stylists, and barbers, are likely to be exposed more than people who just dye their hair on occasion. When people dye their hair or have it dyed, some chemicals in the hair dyes can be absorbed in small amounts through the skin or inhaled from fumes in the air. Because darker dyes have more of some chemicals that may cause cancer, these products are of greatest potential concern. Most of the concern about cancer risk has been with the semi-permanent and permanent dyes. Darker hair dyes tend to use more of these coloring agents. In the presence of hydrogen peroxide, these substances go through chemical reactions to become dyes. They contain colorless substances such as aromatic amines and phenols. These dyes are sometimes referred to as coal-tar dyes because of some of the ingredients in them. They are the most popular types of hair dyes, because the color changes last until the hair is replaced by new growth.
Sheĭescends from an old, very rich family of bankers. Although born in Paris Paris (historical), capital of France, which seems like an oddity in these "exaltedĬircles," she resembles one of those blonde Venetian women of Palma Vecchio Palma Vecchio (1480-1528), a Venetian painter. The Wegeners author of Mosaiques is an expert. In this, Elena Elena Rossini (fictional), modeled on Hélène Kann Allatini (1887-1943), friend of Madrid Madrid (historical), capital of Spain The Wegeners author of Mosaiques whisper delectable and even raunchy, newĪnd scandalous stories out of Rome Rome (historical), capital of Italy and Painter lets Elena Elena Rossini (fictional), modeled on Hélène Kann Allatini (1887-1943), friend of Meanwhile, Andreas Andreas Sparre (fictional), modeled on Einar Magnus Andreas Wegener (b. With deeply earnest eyes that are honed for the appreciation of the arts. That's how Ernesto Ernesto Rossini (fictional), modeled on Eric Allatini (1886–1943), friend of the Wegeners That's how Grete Grete Sparre (fictional), modeled on Gerda Wegener (1885-1940), an art deco painter Infamous, narrow alleys in Cadiz Cádiz (historical), port city in Spain and Antwerp Antwerp (historical), a city in Belgium, voyages of discovery through theīazaars of the Balkans Balkans (historical), region in southeastern Europe and in basement thrift stores of the Hague The Hague (historical), city in the NetherlandsĪnd Amsterdam Amsterdam (historical), capital of the Netherlands! One tries to In a colorful way, wanderings through museums and Married to Hélène Allatini exchange multiple travel impressions with one another Grete Grete Sparre (fictional), modeled on Gerda Wegener (1885-1940), an art deco painterĪnd illustrator and Ernesto Ernesto Rossini (fictional), modeled on Eric Allatini (1886–1943), friend of the Wegeners Translation of Lili Elbe Buch (German Typescript) Caughie, Anna McCue, Matthew Gallagher, Emily Datskou XML transformed into HTML on by Rebecca J.
While I know more about security/computing than the average Joe, I'm not a 'techie'. Are you saying that seamonkey and palemoon won't work in the future/2017 ? same for seamonky and thunderbird as they are community driven projects.' 'servo engine is coming, XUL is close to death.' 'palemoon is using a complete other engine as firefox and people starts collection the xpi extensions because mozilla will remove them, firefox is no longer capable when xul is dropped after 2016 (beginning 2017). But that happened at least once with Seamonkey. 'that's the regular way for all browsers meanwhile, you cant avoid.' Not for all, as long as you don't install a new version of IE an update will usually not change the security settings. Short version, I looked at these browsers years ago and decided not to use them if possible. Either Chrome or Chromium transmites data to 'Google' by default, then there is the issue of the source code. It has been a long time since I studied that one. if anonymous then vpn.Ĭhrome/Chromium/Google, well I just don't trust Google products. so TOR is no option for me, in fact tor is pseudo and slow, files can be manipulated in some bad manner and you wont get it. i use several (passive) methods to secure my system and a browser is only one brick, nothing special. So regular updates with filled security gaps is my first target - like i install windows updates. same for seamonky and thunderbird as they are community driven projects. Palemoon is using a complete other engine as firefox and people starts collection the xpi extensions because mozilla will remove them, firefox is no longer capable when xul is dropped after 2016 (beginning 2017). it also offers a hosts file usage from several sources - those sites are blocked by default. Webextensions are nearly same after june'2016 for all browser.Īgainst annoying ads and some filter options i use uBlock origin in all my browsers - i can transfer very easy settings from one to another and all will act same. Any recommendation to block ads and other unwanted 'stuff' ?Ĭlick to expand.why not? any special reason against?įirefox has upcoming changes and will be more like chrome after 2016, servo engine is coming, XUL is close to death. And as it has turned out, some (Ghostery?) ad blockers do some tracking of their own.īut maybe it is time to install one. For that, a modified HOSTS file seemed to work quite adequately. Īlso, I have never used an ad blocker on any of my own systems. Just simple, safe, effective, secure, robust. Personally, I don't like frequent updates AND having to check the privacy/security settings of new versions. Preferably I wouldn't want a 'suite' product like Firefox. IE is pre-installed anyway, Seamonkey uses the Mozilla engine. I really don't want a Google/Chromium product/clone. A simple example of that is that it seems to remember stuff even if you configure it not to remember login data. Even if you tame it a bit, there are privacy issues. But not exactly ideal from a privacy perspective. User-friendly and convenient layout, sure. By now I have some experience with Firefox on Windows XP. What's not to like about Seamonkey ? Maybe it's the GUI/the way it works. Anything that isn’t part of the final design should be deleted – pasteboard objects, images used for tracing, guides, etc. Next, get rid of any unused objects and layers. Of course be sure that these things aren’t important to the design before running the command. This can delete Stray Points, Unpainted Objects, and Empty Text Paths that may have been mistakenly added during design. Unused layers, empty text lines, stray points, items on the pasteboard, old raster images used for tracing maps – all that adds to the SVG file size.Ī simple way for the initial clean up is to use Illustrator’s ‘Clean Up’ command – Object > Path > Clean Up. Clean Up FileĪs SVG files are simply text files, any extraneous information in the file will be included and ultimately bloat the resulting SVG. AI file before it is exported to SVG that will help tremendously during the website programming phase. Until that day, there are many things that can be done to the native. More compact and efficient file writing is another area which could be radically improved. Adding classes to nodes and animation are hoped for items for future inclusion. While Illustrator has implemented decent support for the SVG standard, there are still quite a few areas in which it is lacking. It shouldn’t come as a surprise that Adobe has been somewhat forced into supporting this web-standard, as in some respects it is an open-source alternative to their dying Flash technology. To be able to refer to the SVG we want to clone, it needs to have an id.Preparing Adobe Illustrator files for SVG interactivityĪdobe Illustrator has made some progress over the years in supporting SVG files, a vector-based format intended for the web. As the previous attributes, if we want to change the color dynamically we need to remove it from the SVG file. In order to edit dynamically its size we need to remove them. The viewBox defines the position and dimension, in user space, of an SVG viewport. Otherwise, when we change the width and height of the duplicated element, we will see part of the viewport instead of scaling it. Now, we need to check in the svg tag the following attributes: As we are going to embed its content this info is redundant and we can remove it: When the SVG is generated should include some lines of code and/or comments providing information. Therefore, duplicate it could be the best approach to use.īelow I will list the steps I follow to implement it. If you are using SVG icons in your project, you may need to change their size or color depending on the situation. Editable: add the SVG markup in your template or duplicate it using use element. Not editable: using it as an img or as a background-image in CSS.There are many ways to use SVG files, but we can distinguish 2 types: Now that you have seen the pros of using this format in modern browsers, I am going to show you how I use it on a responsive website. If you are concerned about cross-browser compatibility, you don't have to worry since all modern browsers support it. SVG allows us to add animations, gradients, transparencies and change its style by CSS code, even though it's very lightweight. SVG ( Scalable Vector Graphics) file is vector-based, unlike other file formats like png, that means it can be scaled to any size and its quality will remain the same. The medication and dosage you are prescribed is safe for you to take, but it is intended for your use only. Recovery is different for everyone and you are no exception. Tell your provider if you are feeling discomfort with any part of your treatment plan so adjustments can be made. Take advantage of behavioral health services when offered, and accept referrals to community resources and social services. Speak up to your provider and tell them what other support you need. Medication is vitally important, but it's only one part of your recovery plan. We expect our patients to learn how to take their medication, follow instructions, and ask questions when in doubt. Knowledge is power and your provider is your teacher. To recover from addiction, it's important to understand the chronic nature of the disease, the effect opioids have on the brain, and how medication works to counteract those effects. Understanding your disease and how to treat it. In fact, all you really need to bring to Ideal Option is a desire and willingness to change – we will guide you through the rest. If you've come to Ideal Option to get your life back, you must be prepared and willing to make changes in your life, sometimes major changes, in order to recover and lead your best life. We do not penalize or expel patients for substance use episodes that occur during treatment. In return, your provider expects you to be honest with them so they can keep you safe and on the road to a stable recovery. Ideal Option is a safe, non-judgmental space where you will be treated with respect and empathy. Your success is central to our mission, and we’re so happy that we can continue to grow with you and for you in even bigger ways. The calendar syncing process varies after. You’ll see the project on the top right of your screen. You can find the calendar URL by clicking on the calendar and then the gold share button. We’re committed to strengthening our industry so you and your business can reach your greatest potential. Step 1: To sync to these calendars you must first start by logging into the project or event and get the calendar URL. Our core values will always reflect those of our pro community-innovation, efficiency, beautiful design, and empowerment. We’re also preparing to expand our marketing, customer support, and community engagement teams to better connect with, support, and celebrate you as you build and grow your business with Aisle Planner.Īisle Planner will remain the same trusted company you have come to know and love. We’ve already begun to bolster our development teams and processes so we can produce new features more quickly, enhance existing tools, and improve functionality. This partnership, built on a shared vision and dedication to the community we serve, will fuel the drive, creativity, and innovation behind Aisle Planner’s powerful software solutions. Fullsteam works with technology companies in various sectors, including the wedding and events industry, to create best-in-class software and payments solutions. Today we’re excited to take the next step in our journey as we announce our new partnership with Fullsteam. While we’ve continued to grow since day one, our mission has never changed: to build an online space that fosters creativity, encourages collaboration, and boosts productivity. Over the last eight years, we’ve continually expanded our product features and tools, and have quickly become the industry’s most comprehensive, intuitive, and seamless online marketing, sales, and project management platform. Please include a vendor list with email contacts, links to websites, and social media handles. Designed by event pros for event pros, Aisle Planner started as an idea to help the modern event professional manage their business more efficiently, become a more effective owner and operator, and empower them to deliver extraordinary client experiences. If an Aisle Planner Pro, please include a minimum of 10 images or screen shots of your planning process for this event within the Aisle Planner platform Include a brief (but detailed) description of the event or photo shoot. Since we wrote our first line of code in 2013, Aisle Planner has been a company that continuously strives to make a difference through the products we design, the platform we develop, and most importantly, the community we build. I'm pretty sure knowing jagex it means if the vein is succesfully mined for pay dirt the depletion timer starts as normal, but the change they made now sounds like if a vein stops being mined after the depletion timer has been started it will instantly start the respawn timer as well. I wish they would be more clear about what they meant here. Veins must be depleted before resetting the 20 second interval, and any veins left abandoned prior to it's final pay-dirt mined will produce only one pay-dirt when mined again."Īny thoughts/interpretations would be great! The first pay-dirt mined after 20 seconds have lapsed from the first successful pay-dirt mined will deplete the upper level veins, rather than having a probability of becoming depleted per ore mined. "The upper level contains 64 additional ore veins that are closer to one another compared to the lower level. Based on what the update says, it sounds like the veins will respawn faster now, potentially before they actually deplete? Looking at the wiki, when you start mining a vein in the upper level, after 20 seconds it will deplete and only once depleted will the respawn timer start. It sounds obvious as to what this means but in practise I can't make sense of it. In the latest update on 13th July 2022 the notes said "The upstairs ore veins no longer need to be completely depleted to start their respawn timer." For more information about account bans, click here. Feel like sharing? Please censor names wherever possible. Report abuse in game and contact Jagex for serious issues. This is not the place to accuse players of wrongdoing. No "Advice Animals" or other image macros. The body of your submission must be related to Old School RuneScape.ĭon't break or promote breaking Jagex/OSRS T&C. The mods here at /r/2007scape aim to make this the number one place to have fun, meet friends, and create memories! Rules of the land Welcome to /r/2007scape, the place to discuss Old School RuneScape! Submit a link Submit a text post Submit a game suggestion Average ground delivery time ranges from 7-14 business days. The ground shipping method used will be determined at Music Direct's discretion. Please Note: Orders that are less than $125 are not guaranteed to ship via FedEx. Orders will be held to ship all back ordered items together when they are all received in stock. Music Direct will not charge additional shipping for any back orders items. Music Direct will contact you with shipping charges for these addresses.Ĭustomers can choose an alternative expedited shipping method but it will not qualify for this free shipping offer. This offer is not included on any shipments to FPO/APO addresses. Music Direct reserves the right to change the terms of this promotion or discontinue this offer at any time. Music Direct reserves the right to select the carrier and ship method within the terms of this offer. This offer cannot be applied to previously placed orders. This offer also excludes Oppo, demos, closeouts/sale items and freight shipped items. **Orders must be at least $49, before tax, to qualify. *Ground shipping to the 48 contiguous states only (FPO/APO excluded). If you continue to see a shipping charge on your order, please check the exclusions listed below. When your order subtotal reaches $49 in the shopping cart the shipping charge for associated qualifying items will automatically be adjusted on your order. Place a qualifying order over $49* and receive FREE DOMESTIC GROUND SHIPPING. Madvillain Madvillainy 2: The Madlib Remix Track Listing: Packaged in a full color jacket of the original CD artwork, the release includes Madlib’s remixes on two pieces of vinyl, comic book insert, and a digital download of the entire album. Previously available only with Stones Throw’s release of Madvillainy 2: THE BOX and a small lot of sought after white label pressings, Madvillainy 2: The Madlib Remix is now being reissued properly on wax. In need of some headphone listening before a ten-hour plane ride to Tokyo, Madlib reworked his classic DOOM collaborative effort Madvillainy in its entirety. But back in 2008, he created one of his more respected forms of alleged musical sacrilege. After witnessing the epic undertaking of his “album per month” Medicine Show series, we were once again reminded. Madlib has never been one to respect convention. Music Direct does not guarantee delivery within that specified time period.Madvillain Madvillainy 2: The Madlib Remix on 2LP + Comic Book Insert + Download |
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